Acute porphyrias are a group of rare genetic metabolic disorders, caused by a defect in one of the enzymes involved in the heme biosynthesis, which results in an abnormally high accumulation of toxic intermediates.Acute porphyrias are characterized by potentially life-threatening attacks and, for some patients, by chronic manifestations that negati
The article touches upon the problem of international use of transboundary rivers by the republics of Central Asia and its legal regulation on the basis of the principles and norms of the international law.Speaking about the problem of transboundary rivers the issue concerned was the navigability of rivers, while in the case of Amudariya and Syrdar
Embryonic stem cells (ESC) are pluripotent and thus can differentiate into every cell type present in the body.Directed differentiation into motor neurons has been described for pluripotent cells.Although neurotrophic factors promote neuronal survival, their role in neuronal commitment is elusive.Here, we developed double-transgenic lines of mouse
Carbon fiber-reinforced silicon carbide (C/SiC) composites were well-established light weight materials combining high specific strength and damage tolerance.For high-temperature applications, protective coatings had to provide oxidation and corrosion resistance.The literature data Credenza introduced various technologies and materials, which were
Crustal stress field can have a significant influence on the way magma is channelled through the crust and erupted explosively at the surface.Large Caldera Forming Eruptions (LCFEs) can erupt hundreds to thousands of cubic kilometres of magma in a relatively short time along fissures under the control of a far-field extensional stress.The associate